diff --git a/build_tests/configure/multiple_set_define.rb b/build_tests/configure/multiple_set_define.rb
new file mode 100644
index 0000000..9a8008b
--- /dev/null
+++ b/build_tests/configure/multiple_set_define.rb
@@ -0,0 +1,8 @@
+configure do
+  check_c_header "math.h", set_define: "HAVE_MATH_H"
+  check_c_header "stdio.h", set_define: "HAVE_STDIO_H"
+end
+
+Rscons::Environment.new(echo: :command) do |env|
+  env.Object("simple.o", "simple.c")
+end
diff --git a/spec/build_tests_spec.rb b/spec/build_tests_spec.rb
index dafef57..435b252 100644
--- a/spec/build_tests_spec.rb
+++ b/spec/build_tests_spec.rb
@@ -1885,6 +1885,17 @@ EOF
       expect(result.stdout).to match /Checking for library 'm'\.\.\. found/
       expect(result.stdout).to match /Checking for program 'ls'\.\.\. .*ls/
     end
+
+    it "aggregates multiple set_define's" do
+      test_dir "configure"
+      result = run_rscons(rsconscript: "multiple_set_define.rb", op: "configure")
+      expect(result.stderr).to eq ""
+      expect(result.status).to eq 0
+      result = run_rscons(rsconscript: "multiple_set_define.rb", op: "build")
+      expect(result.stderr).to eq ""
+      expect(result.status).to eq 0
+      expect(result.stdout).to match /gcc.*-o.*\.o.*-DHAVE_MATH_H\s.*-DHAVE_STDIO_H/
+    end
   end
 
 end